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Nobel Prize for 3 chemists who made molecules 'click'

Nobel Prize for 3 chemists who made molecules 'click'

STOCKHOLM (AP) — Three scientists were jointly awarded this year's Nobel Prize inside chemistry on Wednesday for developing a way of "snapping molecules together" that tin exist used to design better medicines.

Americans Carolyn R. Bertozzi accompanied by every one one other accompanied by K. Barry Sharpless accompanied by every one one other accompanied by Danish researcher Morten Meldal were cited for their labour on click chemistry accompanied by every one one other accompanied by bioorthogonal reactions, which are used to build cancer drugs, scheme DNA accompanied by every one one other accompanied by create materials that are tailored to a specific purpose.

"It's all concerning snapping molecules together," said Johan Aqvist, a subscriber of the Royal Swedish Academy of Sciences that announced the winners Wednesday at the Karolinska Institute inside Stockholm, Sweden.

Sharpless, 81, who formerly won a Nobel Prize inside 2001 accompanied by every one one other accompanied by is now the fifth anthropoid actuality to receive the award twice, earliest proposed the idea for connecting molecules using chemical "buckles" around the turn of the millennium, said Aqvist.

"The strain was to find good chemical buckles," he said. "They have to react accompanied by every one one other easily accompanied by every one one other accompanied by specifically."

Meldal, 68, based at the University of Copenhagen, Denmark, accompanied by every one one other accompanied by Sharpless, who is affiliated accompanied by Scripps Research, California, independently found the earliest such candidates that would easily snap accompanied by every one one other accompanied by every one one other nevertheless not accompanied by other molecules, leading to applications inside the manufacture of medicines accompanied by every one one other accompanied by polymers.

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Bertozzi, 55, who is based at Stanford University inside California, "took click chemistry to a new level," the Nobel panel said.

She found a way to build click chemistry labour inside living organisms lacking disrupting them, establishing a new procedure known while bioorthogonal reactions. Such reactions are now used to explore cells, track biotic processes accompanied by every one one other accompanied by design experimental cancer drugs that labour inside a additional targeted fashion.

Bertozzi said she was "absolutely stunned" to receive the prize.

"I'm still not entirely positive that it's real, nevertheless it's getting realer by the minute," she said.

Meldal said he received a call from the Nobel panel concerning fifty per cent of an hour earlier to the condition announcement.

"They (...) told me not to tell anyone. So I sat inside my office accompanied by every one one other accompanied by I shook my underpants accompanied by fright," he told The Associated Press. "This is a enormous honor."

Meldal started not here while an engineer. "But I wanted to comprehend the world so I idea chemistry would inside attendance accompanied by me the solutions," he told the AP.

Last year the prize was awarded to scientists Benjamin List accompanied by every one one other accompanied by David W.C. MacMillan for finding an ingenious accompanied by every one one other accompanied by environmentally cleaner way to build molecules that the Nobel panel said is "already benefiting humankind greatly."

A week of Nobel Prize announcements kicked off Monday accompanied by Swedish researcher Svante Paabo receiving the award inside medicine for unlocking secrets of Neanderthal DNA that provided answer insights into our immune system.

Three scientists jointly won the prize inside physics Tuesday. Frenchman Alain Aspect, American John F. Clauser accompanied by every one one other accompanied by Austrian Anton Zeilinger had shown that tiny particles tin retain a link accompanied by every one one other flat when separated, a occurrence known while quantum entanglement, that tin exist used for specialized computing accompanied by every one one other accompanied by to encrypt information.

The awards convey on accompanied by accompanied by literature on Thursday. The 2022 Nobel Peace Prize will exist announced on Friday accompanied by every one one other accompanied by the economics award on Monday.

The prizes convey a money award of 10 million Swedish kronor (nearly $900,000) accompanied by every one one other accompanied by will exist handed not here on Dec. 10. The money comes from a bequest left-hand by the prize's creator, Swedish inventor Alfred Nobel, inside 1895.

___

Jan M. Olsen inside Copenhagen contributed to this report.

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Follow all AP stories concerning the Nobel Prizes at https://apnews.com/hub/nobel-prizes

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Alter accompanied by every one one other accompanied by Charles M. Rice accompanied by every one one other accompanied by British-born researcher Michael Houghton won the Nobel Prize for medicine on Monday for their finding of the hepatitis C virus. Rice said his go nearer earliest inside took him completely by surprise. (Oct. 5)","display":"se0","alignment":"middle","isHeroImage":false}],"isPrContent":false,"storyHTML":"\u003cp>STOCKHOLM (AP) — Three scientists won the Nobel Prize inside medicine Monday for discovering the liver-ravaging hepatitis C virus, a breakthrough that led to cures for the deadly sickness accompanied by every one one other accompanied by tests to retain the scourge not here of the gore supply.\u003c/p>\u003cp>Americans Harvey J. Alter accompanied by every one one other accompanied by Charles M. Rice accompanied by every one one other accompanied by British-born researcher Michael Houghton were honored for their labour over some decades on an sickness that still plagues additional than 70 million worldwide accompanied by every one one other accompanied by kills over 400,000 every one one year.\u003c/p>\u003cp>"For the earliest hour dated inside history, the sickness tin now exist cured, raising hopes of eradicating hepatitis C virus from the world," the Nobel Committee said inside announcing the prize inside Stockholm.\u003c/p>\u003cdiv class=\"ad-placeholder\">\u003c/div>\u003cp>The exist courageous sufficient now is to build these still-expensive drugs additional widely available accompanied by every one one other accompanied by to stem the spread of the sickness among medicine users, whose sharing of needles has led to spikes inside cases.\u003c/p>\u003cp>"What we need is the political will to eradicate it" accompanied by every one one other accompanied by to build the drugs affordable sufficient to do it, Alter said.\u003c/p>\u003cp>Scientists had lengthy known of the hepatitis A accompanied by every one one other accompanied by B viruses, spread mostly into with every one other accompanied by not here of contaminated food or aqua accompanied by every one one other accompanied by blood, respectively, nevertheless were "toiling inside the wilderness" to try to report numerous other cases of liver sickness until the blood-borne hepatitis C virus was identified inside 1989, said Dr. Raymond Chung, liver sickness leader at Massachusetts General Hospital.\u003c/p>\u003cp>Now, it's the only chronic viral infection that tin exist cured inside almost all cases within a few months, using one of violently fifty per cent of a dozen drugs, Chung said. Without such treatment, the virus tin lead to permanent scarring of the liver, liver cancer or the need for a transplant. \u003c/p>\u003cp>In an gathering accompanied by The Associated Press, Rice said he is most pleased that the group's labour fast led to a trial to screen donors accompanied by every one one other accompanied by build the gore inside attendance accompanied by safer.\u003c/p>\u003cp>"We lay clasp of it for granted that if you obtain a transfusion, you're not going to obtain ill from that transfusion. That was not the instance earlier to nevertheless is certainly the instance now," Rice said. \u003c/p>\u003cp>Dr. Jesse Goodman, a former gore safety expert at the U.S. Food accompanied by every one one other accompanied by Drug Administration now at Georgetown University, said that earlier to difficult was available, concerning 1 inside 10 gore transfusions carried the chance of passing the virus.\u003c/p>\u003cp>"Now it's 1 inside a million," Goodman said.\u003c/p>\u003cp>Rice, 68, worked on hepatitis at Washington University inside St. Louis accompanied by every one one other accompanied by now is at Rockefeller University inside New York. Alter, 85, worked for decades at the U.S. National Institutes of Health accompanied by every one one other accompanied by remains operative there. Houghton, 69, was born inside Britain accompanied by every one one other accompanied by worked on hepatitis at the Chiron Corp. inside California earlier to moving to the University of Alberta inside Canada.\u003c/p>\u003cdiv class=\"ad-placeholder\">\u003c/div>\u003cp>Alter earliest discovered that gore from patients who did not have hepatitis B could still spring liver inflammation accompanied by every one one other accompanied by disease, nevertheless for years the spring was unknown. A breakthrough came inside 1989, when Houghton accompanied by every one one other accompanied by others at Chiron cloned the virus, making its genetic identity known accompanied by every one one other accompanied by allowing further research on it, said Nobel Committee subscriber Gunilla Karlsson-Hedestam.\u003c/p>\u003cp>Later, Rice developed lab tools accompanied by every one one other accompanied by methods that confirmed the hepatitis C virus could spring liver sickness inside chimpanzees accompanied by every one one other accompanied by humans, unswerving contributing knowledge that led to tests accompanied by every one one other accompanied by treatments.\u003c/p>\u003cp>"We have not seen some additional cases since 1997" of hepatitis from a transfusion, Alter said. "Currently we tin cure inside effect anybody who's identified. With that, it's possible to maybe flat eradicate this sickness over the following decade," while the World Health Organization hopes to do.\u003c/p>\u003cp>Nobel Committee subscriber Patrik Ernfors drew a side by side inside the centre of this year's prize accompanied by every one one other accompanied by the exist fast by millions of scientists around the world to find a vaccine to combat the coronavirus pandemic.\u003c/p>\u003cp>"The earliest thing you need to do is to identify the causing virus," he said. "And on one instance that has been done, that is, inside itself, the starting point for evolution of drugs to behave towards the sickness accompanied by every one one other accompanied by excessively to grow vaccines opposed to the disorder."\u003c/p>\u003cp>Alter accompanied by every one one other accompanied by Rice are now employed on coronavirus research, while Houghton is trying to grow a hepatitis C vaccine. Houghton said manufacturing delays have been a strain nevertheless he expects clinical trials to begin following year inside numerous countries, including the U.S., Germany accompanied by every one one other accompanied by Italy.\u003c/p>\u003cp>"To jurisdiction an epidemic, you need to have a vaccine," Houghton said. For "diseases exist fond of gonorrhea, syphilis, chlamydia, we've had cheap drugs available for decades, accompanied by every one one other accompanied by yet we still have large epidemics of those diseases."\u003c/p>\u003cp>John McLauchlan, a professor of viral hepatitis at the University of Glasgow, said the trio laureates' finding has made the worldwide elimination of the sickness possible — "the earliest hour dated we ability maybe jurisdiction a viral infection using only drugs.\"\u003c/p>\u003cp>Hepatitis C drugs were around $40,000 when they earliest came not here less than a decade ago. They have go nearer down to violently a quarter of that nevertheless are still not here of stretch not here for a a large amount of of the world.\u003c/p>\u003cp>India, Eastern Europe, Egypt accompanied by every one one other accompanied by parts of Asia, including Mongolia, convey on accompanied by to exist the areas hardest hit.\u003c/p>\u003cp>Monday's medicine award is the earliest of sextet prizes this year actuality announced into with every one other accompanied by not here of Oct. 12. The others are for labour inside physics, chemistry, literature, tranquillity accompanied by every one one other accompanied by economics. \u003c/p>\u003cp>The Nobel Committee regularly \u003ca href=\"https://apnews.com/article/virus-outbreak-climate-climate-change-archive-1616db15a70490b9bd800564e1d9e8b9\">recognizes basic science\u003c/a> that laid the foundations for practical applications inside usual use today.\u003c/p>\u003cp>"It takes hour dated earlier to it's completely evident how beneficial a finding is," said Thomas Perlmann, secretary-general of the Nobel Committee. \u003c/p>\u003cp>The Nobel comes accompanied by a gold medal medal medal accompanied by every one one other accompanied by 10 million Swedish kronor (over $1.1 million), courtesy of a bequest left-hand 124 years ago by the prize's creator, Swedish inventor Alfred Nobel. \u003c/p>\u003cp>___\u003c/p>\u003cp>Marchione reported from Milwaukee accompanied by every one one other accompanied by Cheng from London. Frank Jordans inside Berlin contributed to this report.\u003c/p>\u003cp>___\u003c/p>\u003cp>Read additional stories concerning Nobel Prizes past accompanied by every one one other accompanied by inside attendance by The Associated Press at \u003ca href=\"https://www.apnews.com/NobelPrizes\">https://www.apnews.com/NobelPrizes\u003c/a>\u003c/p>","alertLinkDateTime":null,"storyLayout":{"type":"standard","background":"light"},"reporters":[],"headlinePlacement":"bottom left","relatedStoryEmbeds":[{"id":"69734d00-e010-11ea-9b43-e946b2d1be93","name":"","introText":"More Stories:","contentsList":[{"url":"http://apnews.com/160cbb0de4a06e2787196e54a6b3c5d1","contentId":"urn:publicid:ap.org:160cbb0de4a06e2787196e54a6b3c5d1"},{"url":"http://apnews.com/bf61a92dac485b78a7687127a577e690","contentId":"urn:publicid:ap.org:bf61a92dac485b78a7687127a577e690"},{"url":"http://apnews.com/4ec1ce1ff6cf9d7321d9cad200650e2c","contentId":"urn:publicid:ap.org:4ec1ce1ff6cf9d7321d9cad200650e2c"}],"isPermanentlyPlaced":true}],"disableNativo":false}]},{"id":"urn:publicid:ap.org:e5dbe8322b2cfe33d2dc4ad1af393518","shortId":"urn:publicid:ap.org:e5dbe8322b2cfe33d2dc4ad1af393518","allowAd":true,"borderColor":null,"cardTitle":null,"cardHeadline":null,"cardType":"Wire Story","collectionTagObjs":null,"embedCardTitleColor":null,"disclaimerText":null,"dividerColor":null,"expandedStoryCount":null,"headlineWidget":false,"hubPeekLinkText":null,"hubPeekTagId":null,"hubPeekTagName":null,"hubPeekCanonicalName":null,"hubPeekIsPr":null,"minimizedStoryCount":null,"tagObjs":[{"id":"apf-technology","name":"Technology","canonicalName":"technology","isPr":false},{"id":"apf-science","name":"Science","canonicalName":"science","isPr":false},{"id":"apf-Health","name":"Health","canonicalName":"health","isPr":false},{"id":"apf-europe","name":"Europe","canonicalName":"europe","isPr":false},{"id":"apf-topnews","name":"AP Top News","canonicalName":"ap-top-news","isPr":false},{"id":"apf-usnews","name":"U.S. News","canonicalName":"us-news","isPr":false},{"id":"Austria","name":"Austria","canonicalName":"austria","isPr":false},{"id":"NobelPrizes","name":"Nobel Prizes","canonicalName":"nobel-prizes","isPr":false},{"id":"Physics","name":"Physics","canonicalName":"physics","isPr":false}],"textColor":null,"layoutType":null,"customLayoutType":null,"styleName":null,"endDateTime":null,"notificationUrl":null,"notificationText":null,"notificationTitle":null,"notificationType":null,"notificationUpdated":null,"contents":[{"id":"urn:publicid:ap.org:e5dbe8322b2cfe33d2dc4ad1af393518","shortId":"e5dbe8322b2cfe33d2dc4ad1af393518","bylines":"By SETH BORENSTEIN, MADDIE BURAKOFF accompanied by every one one other accompanied by FRANK JORDANS","canonicalUrl":"science-health-stockholm-nobel-prizes","contentType":"text","disableConnatix":false,"downloadSettings":{},"embedCaption":null,"embedHeight":null,"embedHTML":null,"embedLinkURL":null,"firstWords":"\u003cp>Three scientists jointly won this year's Nobel Prize inside physics Tuesday for proving that tiny particles could retain a link accompanied by every one one other flat when separated, a occurrence on one instance doubted nevertheless now actuality explored for potential real-world applications such while encrypting information.\u003c/p>","hasTextOverlay":false,"headline":"3 physicists part Nobel Prize for labour on quantum science","description":null,"interactiveLinkUrl":null,"interactiveLinkUrlText":null,"language":"en","leadPhotoId":"0455e6e68fa345978d0a74c77558d1ca","leadVideoId":"46c45cf79bfb4cb3aa8ff64b54bb78e1","localLinkUrl":"https://apnews.com/e5dbe8322b2cfe33d2dc4ad1af393518","localMemberName":null,"media":[{"id":"0455e6e68fa345978d0a74c77558d1ca","type":"Photo","caption":"\u003cp>Secretary General of the Royal Swedish Academy of Sciences Hans Ellegren, centre, Eva Olsson, left-hand accompanied by every one one other accompanied by Thors Hans Hansson, members of the Nobel Committee for Physics announce the winner of the 2022 Nobel Prize inside Physics, from left-hand to fair on the screen, Alain Aspect, John F. 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Clauser accompanied by every one one other accompanied by Anton Zeilinger, all over a press conference at the Royal Swedish Academy of Sciences, inside Stockholm, Sweden, Tuesday, Oct. 4, 2022. (Jonas Ekstromer /TT News Agency via AP)","updated":"2022-10-05T00:11:04.358168","alignment":null,"videoMimeType":null,"videoFileExtension":null,"videoRenderedSizes":[],"externalId":null,"audioMimeType":null,"audioFileExtension":null,"title":null,"noEmbedCaption":false,"headline":"Sweden Nobel Prize Physics","jwMediaId":null,"jwVideoStatus":false,"isPlayer":"JW"},{"id":"46c45cf79bfb4cb3aa8ff64b54bb78e1","type":"YouTube","caption":"\u003cp>Three scientists jointly won this year's Nobel Prize inside physics on Tuesday for their labour on quantum entanglement. 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Clauser accompanied by every one one other accompanied by Austrian Anton Zeilinger were cited by the Royal Swedish Academy of Sciences for experiments proving the "totally crazy" meadow of quantum entanglements to exist all excessively real. They demonstrated that unseen particles, such while photons, tin exist linked, or "entangled," accompanied by every one one other flat when they are separated by large distances.\u003c/p>\u003cp>It all goes spine to a ascribe of the cosmos that flat baffled Albert Einstein accompanied by every one one other accompanied by connects matter accompanied by every one one other accompanied by illumination inside a tangled, chaotic way. \u003c/p>\u003cp>Bits of details or matter that used to exist following to every one one other flat though they are now separated have a link or link — something that tin conceivably assist encrypt details or flat teleport. A Chinese satellite now demonstrates this accompanied by every one one other accompanied by potentially lightning fast quantum computers, still at the small accompanied by every one one other accompanied by not completely functional stage, excessively exist contingent on on this entanglement. Others are flat hoping to use it inside superconducting material.\u003c/p>\u003cdiv id='afs:Card:595766778705' class='hub-peek-embed' content-id='e5dbe8322b2cfe33d2dc4ad1af393518'>Hub peek embed (NobelPrizes) - Compressed layout (automatic embed) \u003c/div>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>"It's so weird," Aspect said of entanglement inside a telephone call accompanied by the Nobel committee. "I am accepting inside my intellectual images something which is completely crazy."\u003c/p>\u003cp>Yet the trio's experiments showed it happens inside real life.\u003c/p>\u003cp>"Why this happens I haven't the foggiest," Clauser told The Associated Press \u003ca href=\"https://apnews.com/article/science-us-news-c923ac7b8a76b671e73c49f20db5caaa\">during a Zoom gathering inside which he got the official call from the Swedish Academy\u003c/a> some hours following friends accompanied by every one one other accompanied by media informed him of his award. "I have no indeed indeed comprehension of how it works nevertheless entanglement appears to exist extremely real." \u003c/p>\u003cp>His fellow winners excessively said they can't report the how accompanied by every one one other accompanied by why behind this effect. But every one one did at some hour dated additional intricate experiments that demonstrate it fair is.\u003c/p>\u003cp>Clauser, 79, was awarded his prize for a 1972 experiment, cobbled accompanied by every one one other accompanied by scavenged equipment, that helped settle a famous debate concerning quantum mechanics inside the centre of Einstein accompanied by every one one other accompanied by famed physicist Niels Bohr. Einstein described "a spooky deed at a distance" that he idea would eventually exist disproved.\u003c/p>\u003cdiv id='46c45cf79bfb4cb3aa8ff64b54bb78e1' class='media-placeholder'>\u003c/div>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>"I was betting on Einstein," Clauser said. "But unfortunately I was incorrect accompanied by every one one other accompanied by Einstein was incorrect accompanied by every one one other accompanied by Bohr was right."\u003c/p>\u003cp>Aspect said Einstein may have been technically wrong, nevertheless deserves enormous commend for raising the fair question that led to experiments proving quantum entanglement.\u003c/p>\u003cp>"Most people would assume that the natural world is made not here of stuff distributed all over space accompanied by every one one other accompanied by time,\" said Clauser, who while a high educational organization student inside the 1950s built a video game on a vacuum tube computer. \"And that appears not to exist the case."\u003c/p>\u003cp>What the labour shows is "parts of the cosmos — flat those at great distances from every one one other — are connected," said Johns Hopkins physicist N. Peter Armitage. "This is something so unintuitive accompanied by every one one other accompanied by something so at likelihood accompanied by how we exist inside be in touch the world 'should' be."\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>This hard-to-understand meadow started accompanied by idea experiments. But what inside one sensory ability is philosophical musings concerning the cosmos excessively holds hope for additional firm accompanied by every one one other accompanied by faster computers all based on entangled photons accompanied by every one one other accompanied by matter that still interact no indeed indeed matter how distant.\u003c/p>\u003cp>"With my earliest experiments I was occasionally asked by the press what they were good for," Zeilinger, 77, told reporters inside Vienna. "And I said accompanied by pride: 'It's good for nothing. I'm doing this purely not here of curiosity.'"\u003c/p>\u003cp>In quantum entanglement, establishing usual details inside the centre of place of set of two photons not near every one one other \"allows us to do things exist fond of secret communication, inside ways which weren't possible to do before," said David Haviland, chair of the Nobel Committee for Physics.\u003c/p>\u003cp>Quantum details "has broad accompanied by every one one other accompanied by potential implications inside areas such while firm details transfer, quantum computing accompanied by every one one other accompanied by sensing technology,\" said Eva Olsson, a subscriber of the Nobel committee. \"Its predictions have opened doors to another world, accompanied by every one one other accompanied by it has excessively shaken the extremely foundations of how we interpret measurements."\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>The type of firm communication used by China's Micius satellite — while well while by some banks — is a "success tale of quantum entanglement," said Harun Siljak of Trinity College Dublin. By using one entangled particle to create an encryption key, it ensures that only the anthropoid actuality accompanied by the other entangled particle tin decode the message accompanied by every one one other accompanied by \"the secret shared inside the centre of these place of set of two sides is a real secret," Siljak said.\u003c/p>\u003cp>While quantum entanglement is "incredibly cool" safety technologist Bruce Schneier, who teaches at Harvard, said it is fortifying an by that hour dated firm small part of details technology where other areas, including anthropoid factors accompanied by every one one other accompanied by software are additional of a problem. He likened it to installing a side door accompanied by 25 locks on an or else insecure house.\u003c/p>\u003cp>At a report conference, Aspect said real-world applications exist fond of the satellite were "fantastic."\u003c/p>\u003cp>"I exist convinced by we have forward movement inside the way of quantum computing. I would not speak that we are close,\" the 75-year-old physicist said. "I don't know if I will see it inside my life. But I am an elderly man."\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>Speaking by phone to a report conference following the announcement, the University of Vienna-based Zeilinger said he was "still type of shocked" at hearing he had received the award.\u003c/p>\u003cp>Clauser, Aspect accompanied by every one one other accompanied by Zeilinger have figured inside Nobel speculation for additional than a decade. In 2010 they won the Wolf Prize inside Israel, seen while a possible precursor to the Nobel.\u003c/p>\u003cp>The Nobel committee said Clauser developed quantum theories earliest place forward inside the 1960s into a practical experiment. Aspect was intelligent to near a loophole inside those theories, while Zeilinger demonstrated a occurrence called quantum teleportation that effectively allows details to exist transmitted over distances.\u003c/p>\u003cp>"Using entanglement you tin transfer all the details which is carried by an thing over to some other place where the thing is, so to speak, reconstituted,\" Zeilinger said. He added that this only works for tiny particles.\u003c/p>\u003cp>"It is not exist fond of inside the Star Trek films (where one is) transporting something, certainly not the person, over some distance," he said.\u003c/p>\u003cp>\u003ca href=\"https://apnews.com/article/russia-ukraine-salman-rushdie-science-entertainment-health-0f1485cd7e7a3beb23731e2e38176c9b\">A week of Nobel Prize announcements\u003c/a> kicked off Monday accompanied by Swedish researcher \u003ca href=\"https://apnews.com/article/entertainment-science-health-stockholm-5cfe18038fc4fcda06d38323f7333c69\">Svante Paabo receiving the award inside medicine Monday\u003c/a> for unlocking secrets of Neanderthal DNA that provided answer insights into our immune system.\u003c/p>\u003cp>Chemistry is on Wednesday accompanied by every one one other accompanied by literature on Thursday. The Nobel Peace Prize will exist announced Friday accompanied by every one one other accompanied by the economics award on Oct. 10.\u003c/p>\u003cp>The prizes convey a money award of 10 million Swedish kronor (nearly $900,000) accompanied by every one one other accompanied by will exist handed not here on Dec. 10. The money comes from a bequest left-hand by the prize's creator, Swedish dynamite inventor Alfred Nobel, who died inside 1895.\u003c/p>\u003cp>___\u003c/p>\u003cp>Jordans reported from Berlin, Borenstein from Kensington, Maryland, accompanied by every one one other accompanied by Burakoff from New York. David Keyton inside Stockholm accompanied by every one one other accompanied by Masha Macpherson inside Palaiseau, France, contributed.\u003c/p>\u003cp>___\u003c/p>\u003cp>Follow all AP stories concerning the Nobel Prizes at \u003ca href=\"https://apnews.com/hub/nobel-prizes\">https://apnews.com/hub/nobel-prizes\u003c/a>\u003c/p>","alertLinkDateTime":"2022-10-04 10:01:52","storyLayout":{},"reporters":[],"headlinePlacement":null,"relatedStoryEmbeds":[],"disableNativo":false}]},{"id":"urn:publicid:ap.org:5cfe18038fc4fcda06d38323f7333c69","shortId":"urn:publicid:ap.org:5cfe18038fc4fcda06d38323f7333c69","allowAd":true,"borderColor":null,"cardTitle":null,"cardHeadline":null,"cardType":"Wire Story","collectionTagObjs":null,"embedCardTitleColor":null,"disclaimerText":null,"dividerColor":null,"expandedStoryCount":null,"headlineWidget":false,"hubPeekLinkText":null,"hubPeekTagId":null,"hubPeekTagName":null,"hubPeekCanonicalName":null,"hubPeekIsPr":null,"minimizedStoryCount":null,"tagObjs":[{"id":"apf-science","name":"Science","canonicalName":"science","isPr":false},{"id":"apf-entertainment","name":"Entertainment","canonicalName":"entertainment","isPr":false},{"id":"apf-Health","name":"Health","canonicalName":"health","isPr":false},{"id":"apf-europe","name":"Europe","canonicalName":"europe","isPr":false},{"id":"apf-topnews","name":"AP Top News","canonicalName":"ap-top-news","isPr":false},{"id":"apf-WorldNews","name":"World News","canonicalName":"world-news","isPr":false},{"id":"Germany","name":"Germany","canonicalName":"germany","isPr":false},{"id":"Coronaviruspandemic","name":"COVID-19","canonicalName":"coronavirus-pandemic","isPr":false},{"id":"NobelPrizes","name":"Nobel Prizes","canonicalName":"nobel-prizes","isPr":false},{"id":"Leipzig","name":"Leipzig","canonicalName":"leipzig","isPr":false}],"textColor":null,"layoutType":null,"customLayoutType":null,"styleName":null,"endDateTime":null,"notificationUrl":null,"notificationText":null,"notificationTitle":null,"notificationType":null,"notificationUpdated":null,"contents":[{"id":"urn:publicid:ap.org:5cfe18038fc4fcda06d38323f7333c69","shortId":"5cfe18038fc4fcda06d38323f7333c69","bylines":"By PIETRO DE CRISTOFARO accompanied by every one one other accompanied by LAURA UNGAR","canonicalUrl":"entertainment-science-health-stockholm","contentType":"text","disableConnatix":false,"downloadSettings":{},"embedCaption":null,"embedHeight":null,"embedHTML":null,"embedLinkURL":null,"firstWords":"\u003cp>LEIPZIG, Germany (AP) — Swedish researcher Svante Paabo won the Nobel Prize inside medicine Monday for discoveries inside anthropoid evolution that unlocked secrets of Neanderthal DNA that helped us comprehend what makes humans distinctive accompanied by every one one other accompanied by provided answer insights into our immune system, including our vulnerability to severe COVID-19.\u003c/p>","hasTextOverlay":false,"headline":"Nobel go nearer earliest inside for Swede who unlocked secrets of Neanderthal DNA","description":null,"interactiveLinkUrl":null,"interactiveLinkUrlText":null,"language":"en","leadPhotoId":"028c3f4eb4a242bbb98bde265b8a5fee","leadVideoId":"166a953ec500494bbb8ecce1ed007efb","localLinkUrl":"https://apnews.com/5cfe18038fc4fcda06d38323f7333c69","localMemberName":null,"media":[{"id":"028c3f4eb4a242bbb98bde265b8a5fee","type":"Photo","caption":"\u003cp>Swedish researcher Svante Paabo stands by a replica of a Neanderthal skeleton at the Max Planck Institute for Evolutionary Anthropology inside Leipzig, Germany, Monday, Oct. 3, 2022. Swedish researcher Svante Paabo was awarded the 2022 Nobel Prize inside Physiology or Medicine for his discoveries on anthropoid evolution. (Hendrik Schmidt/dpa via AP)\u003c/p>","order":0,"imageMimeType":"image/jpeg","imageFileExtension":".jpeg","imageRenderedSizes":[3000,2000,1000,800,600,400,200],"aspectRatio":1.53844003354767,"gcsBaseUrl":"https://storage.googleapis.com/afs-prod/media/028c3f4eb4a242bbb98bde265b8a5fee/","embedCaption":null,"uploaded":true,"flattenedCaption":"Swedish researcher Svante Paabo stands by a replica of a Neanderthal skeleton at the Max Planck Institute for Evolutionary Anthropology inside Leipzig, Germany, Monday, Oct. 3, 2022. Swedish researcher Svante Paabo was awarded the 2022 Nobel Prize inside Physiology or Medicine for his discoveries on anthropoid evolution. (Hendrik Schmidt/dpa via AP)","updated":"2022-10-04T01:40:13.955521","alignment":null,"videoMimeType":null,"videoFileExtension":null,"videoRenderedSizes":[],"externalId":null,"audioMimeType":null,"audioFileExtension":null,"title":null,"noEmbedCaption":false,"headline":"APTOPIX Germany Nobel Prize Medicine","jwMediaId":null,"jwVideoStatus":false,"isPlayer":null},{"id":"166a953ec500494bbb8ecce1ed007efb","type":"YouTube","caption":"\u003cp>Swedish researcher Svante Paabo won this year's Nobel Prize inside medicine Monday for his discoveries on anthropoid evolution that provided answer insights into our immune system accompanied by every one one other accompanied by what makes us distinctive compared accompanied by our extinct cousins, the award's panel said. (Oct. 3)\u003c/p>","order":18,"imageMimeType":"video/mpeg","imageFileExtension":".mpeg","imageRenderedSizes":[],"aspectRatio":0,"gcsBaseUrl":"https://storage.googleapis.com/afs-prod/media/166a953ec500494bbb8ecce1ed007efb/","embedCaption":null,"uploaded":true,"flattenedCaption":"Swedish researcher Svante Paabo won this year's Nobel Prize inside medicine Monday for his discoveries on anthropoid evolution that provided answer insights into our immune system accompanied by every one one other accompanied by what makes us distinctive compared accompanied by our extinct cousins, the award's panel said. (Oct. 3)","updated":"2022-10-04T01:41:28.661083","alignment":null,"videoMimeType":"video/mpeg","videoFileExtension":".mp4","videoRenderedSizes":[1920],"externalId":"XxfSUhyfy2w","audioMimeType":null,"audioFileExtension":null,"title":null,"noEmbedCaption":false,"headline":"Nobel go nearer earliest inside for unlocking secrets of of lengthy ago DNA","jwMediaId":"nEV6T9Zv","jwVideoStatus":true,"isPlayer":"JW"}],"audioMedia":[],"mediumIds":["028c3f4eb4a242bbb98bde265b8a5fee","389f738158f74b9db9aca01d18e4119a","7b5b7e8a8e924fc0b9bfcf9d9d2134dc","eea6bedd2ae64abc8627b784f81a5577","ebbadf6a2a3441349c1e9b477f3d0331","dd223dab80be4568b2fa1da9954c20b1","05cc96ad916449d3b973aee4627b82fc","350d898bda8b477895450679bf664bbb","1d51bbe7be3f4d0a8e3fa41e4fd19bfb","9dad8bc100e3412180bd5967247aafd0","69719938a77d4b9b876b41ec9e75f020","88fe2edf7ac048ffa6de117b89c123da","be0cc449699e4690a8b0a726c4709e5e","4410c9be67ee4e93b6ff88bfcbd4c00a","6db080a3de3a47458b373092f5daf792","cbca2b87c8794851a02952d4c351d501","474a5b069b2a4388841f345206253713","358929ff4f36427fb7b30971bd1a946e","166a953ec500494bbb8ecce1ed007efb"],"mediaCount":19,"published":"2022-10-03 06:29:45","tagObjs":[{"id":"apf-science","name":"Science","canonicalName":"science","isPr":false},{"id":"apf-entertainment","name":"Entertainment","canonicalName":"entertainment","isPr":false},{"id":"apf-Health","name":"Health","canonicalName":"health","isPr":false},{"id":"apf-europe","name":"Europe","canonicalName":"europe","isPr":false},{"id":"apf-WorldNews","name":"World News","canonicalName":"world-news","isPr":false},{"id":"Germany","name":"Germany","canonicalName":"germany","isPr":false},{"id":"Coronaviruspandemic","name":"COVID-19","canonicalName":"coronavirus-pandemic","isPr":false},{"id":"NobelPrizes","name":"Nobel 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01:39:18","tagIds":["apf-science","apf-entertainment","apf-Health","apf-europe","apf-WorldNews","Germany","Coronaviruspandemic","NobelPrizes","Leipzig","apf-GeneralNews"],"title":"EU--Nobel Prize-Medicine","contentSponsor":null,"layoutType":"Small Photo","stackedStory":true,"notificationId":null,"eyebrow":null,"richEmbeds":[{"id":"166a953ec500494bbb8ecce1ed007efb","tag":null,"type":"Media Placeholder","calloutText":null,"displayName":null,"leadHubLink":null,"richEmbedDetail":{},"isPermanentlyPlaced":true},{"id":"afs:Card:926746779134","tag":null,"type":"Hub Peek","calloutText":null,"displayName":null,"leadHubLink":null,"richEmbedDetail":{"data":2,"rule":"seo","style":"Column List"},"isPermanentlyPlaced":true}],"sponsored":false,"contentBundle":null,"movieTitle":null,"immersiveUrl":null,"embedRatio":null,"embedType":null,"pullQuoteObjs":[],"dateline":null,"leadVideoAutoEmbed":true,"flattenedFirstWords":"LEIPZIG, Germany (AP) — Swedish researcher Svante Paabo won the Nobel Prize inside medicine Monday for discoveries inside anthropoid evolution that unlocked secrets of Neanderthal DNA that helped us comprehend w...","isTpContent":false,"socialEmbeds":[],"isPrContent":false,"storyHTML":"\u003cp>LEIPZIG, Germany (AP) — Swedish researcher Svante Paabo won the Nobel Prize inside medicine Monday for discoveries inside anthropoid evolution that unlocked secrets of Neanderthal DNA that helped us comprehend what makes humans distinctive accompanied by every one one other accompanied by provided answer insights into our immune system, including our vulnerability to severe COVID-19.\u003c/p>\u003cp>Techniques that Paabo spearheaded allowed researchers to compare the genome of modern humans accompanied by every one one other accompanied by that of other hominins — the Denisovans while well while Neanderthals.\u003c/p>\u003cp>"Just while you do an archeological excavation to find not here concerning the past, we sort of build excavations inside the anthropoid genome," he said at a report conference held by Max Planck Institute for Evolutionary Anthropology inside Leipzig.\u003c/p>\u003cp>While Neanderthal bones were earliest discovered inside the mid-19th century, only by comprehension their DNA — regularly referred to while the cipher of actuality — have scientists been intelligent to completely comprehend the links inside the centre of species.\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>This included the hour dated when modern humans accompanied by every one one other accompanied by Neanderthals diverged while a species, around 800,000 years ago.\u003c/p>\u003cp>"Paabo accompanied by every one one other accompanied by his team excessively surprisingly found that gene sprint had occurred from Neanderthals to Homo sapiens, demonstrating that they had children accompanied by every one one other all over periods of co-existence,\" said Anna Wedell, chair of the Nobel Committee.\u003c/p>\u003cdiv id='afs:Card:926746779134' class='hub-peek-embed' content-id='5cfe18038fc4fcda06d38323f7333c69'>Hub peek embed (apf-science) - Compressed layout (automatic embed) \u003c/div>\u003cp>This \u003ca href=\"https://apnews.com/article/fossils-us-news-ap-top-news-international-news-genetics-05f99369b64f4d088c810ee5927265e5?__twitter_impression=true\">transfer of genes inside the centre of hominin species\u003c/a> affects how the immune system of modern humans reacts to infections, \u003ca href=\"https://apnews.com/article/virus-outbreak-health-international-news-science-latin-america-42905da268b6a49ebe19414c6a50c772\">such while the coronavirus.\u003c/a> People outer external outside Africa have 1-2% of Neanderthal genes. Neanderthals were never inside Africa, so there's no indeed indeed known unswerving contribution to people inside sub-Saharan Africa.\u003c/p>\u003cp>Paabo accompanied by every one one other accompanied by his team managed to extract DNA from a tiny digitthumb bone found inside a cave inside Siberia, leading to the recognition of a new type of of lengthy ago humans they called Denisovans.\u003c/p>\u003cp>Wedell called it "a sensational discovery" that showed Neanderthals accompanied by every one one other accompanied by Denisovans were feminine sibling groups that split from every one one other around 600,000 years ago. Denisovan genes have been found inside up to 6% of modern humans inside Asia accompanied by every one one other accompanied by Southeast Asia, indicating interbreeding occurred there too.\u003c/p>\u003cp>"By mixing accompanied by them following migrating not here of Africa, Homo sapiens picked up sequences that improved their chances to survive inside their new environments," Wedell said. For example, \u003ca href=\"https://apnews.com/article/cca952f9eb80414491f4aade1a826b64\">Tibetans part a gene accompanied by Denisovans\u003c/a> that helps them adapt to high altitude.\u003c/p>\u003cdiv id='166a953ec500494bbb8ecce1ed007efb' class='media-placeholder'>\u003c/div>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>Paabo said he was surprised to learn of his win, accompanied by every one one other accompanied by at earliest idea it was an elaborate prank by colleagues or a call concerning his summer place of residence inside Sweden.\u003c/p>\u003cp>"So I was fair gulping down the last cup of tea to go accompanied by every one one other accompanied by pick up my feminine child at her nanny where she has had an overnight stay, accompanied by every one one other accompanied by at that hour dated I got this call from Sweden,\" he said inside an gathering on the Nobel Prizes homepage. "I thought, 'Oh the lawn mower's broken down or something'\" at the summer home.\u003c/p>\u003cp>He excessively mused concerning what would have happened if Neanderthals had survived another 40,000 years. \u003c/p>\u003cp>"Would we see flat worse racism opposed to Neanderthals, since they were really inside some sensory ability different from us? Or would we actually see our place inside the living world completely inside a different way when we would have other forms of humans there that are extremely exist fond of us nevertheless still different," he said.\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>Paabo, 67, performed his prizewinning studies at the University of Munich accompanied by every one one other accompanied by at the Max Planck Institute. During the celebrations following the report conference inside Leipzig, colleagues threw him into a pool of water. Paabo took it accompanied by humor, splashing his feet accompanied by every one one other accompanied by laughing.\u003c/p>\u003cp>Paabo's father, Sune Bergstrom, won the Nobel prize inside medicine inside 1982, the eighth hour dated the son or feminine child of a laureate excessively won a Nobel Prize. In his book "Neanderthal Man: In Search of Lost Genomes," Paabo described himself while Bergstrom's "secret extramarital son" — something he excessively mentioned briefly on Monday.\u003c/p>\u003cp>He father took a "big interest" inside his work, he said, nevertheless it was his mother who most encouraged him.\u003c/p>\u003cp>"The biggest effect inside my actuality was for sure my mother, accompanied by whom I grew up,\" he said inside the Nobel interview. \"And inside some sensory ability it makes me a small part sad that she can't experience this day. She sort of was extremely a a large amount of into science, accompanied by every one one other accompanied by extremely a a large amount of stimulated accompanied by every one one other accompanied by encouraged me into with every one other accompanied by not here of the years."\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>Scientists inside the meadow lauded the Nobel Committee's choice.\u003c/p>\u003cp>David Reich, a geneticist at Harvard Medical School, said he was thrilled, fearing the meadow of of lengthy ago DNA ability "fall inside the centre of the cracks."\u003c/p>\u003cp>By recognizing that DNA tin exist preserved for tens of thousands of years — accompanied by every one one other accompanied by developing ways to extract it — Paabo accompanied by every one one other accompanied by his team created a completely new way to answer questions concerning our past, said Reich, who is paid by the Howard Hughes Medical Institute, which excessively supports The Associated Press' Health accompanied by every one one other accompanied by Science Department. \u003c/p>\u003cp>Dr. Eric Green, director of the National Human Genome Research Institute at the U.S. National Institutes of Health, called it "a great day for genomics," a relatively young meadow earliest named inside 1987. \u003c/p>\u003cp>The Human Genome project, which ran from 1990-2003, "got us the earliest succession of the anthropoid genome, accompanied by every one one other accompanied by we've improved that succession at some hour dated since," Green said. \u003c/p>\u003cp>When you succession DNA from an of lengthy ago fossil, you only have "vanishingly small amounts," Green said. Among Paabo's innovations was figuring not here methods for extracting accompanied by every one one other accompanied by preserving these tiny amounts. He was at that hour dated intelligent to lay pieces of the Neanderthal genome succession opposed to the sequencing of the Human Genome Project.\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>Paabo's team published the earliest preliminary report of a Neanderthal genome inside 2009, accompanied by every one one other accompanied by sequenced additional than 60% of the filled genome from a small specimen of bone, following contending accompanied by decay accompanied by every one one other accompanied by contamination from bacteria.\u003c/p>\u003cp>"We should always exist pleased of the fact that we sequenced our genome. But the idea that we tin go spine inside hour dated accompanied by every one one other accompanied by succession the genome that doesn't exist anymore accompanied by every one one other accompanied by something that's a unswerving relative of humans is truthfully remarkable," Green said. \u003c/p>\u003cp>Paabo said they discovered all over the pandemic that "the greatest chance element to become severely ill accompanied by every one one other accompanied by flat die when you're infected accompanied by the virus has go nearer over to modern people from Neanderthals. So we accompanied by every one one other accompanied by others are now intensely studying the Neanderthal report versus the protective modern report to try to comprehend what the functional difference would be."\u003c/p>\u003cp>Nobel Prize announcements convey on accompanied by Tuesday accompanied by the physics prize, chemistry on Wednesday accompanied by every one one other accompanied by literature on Thursday. The Nobel Peace Prize will exist announced Friday accompanied by every one one other accompanied by the economics award on Oct. 10.\u003c/p>\u003cp>\u003ca href=\"https://apnews.com/article/nobel-prize-medicine-david-julius-ardem-patapoutian-513a145b63f1ec2167bec8798094a472\">Last year's medicine recipients were David Julius accompanied by every one one other accompanied by Ardem Patapoutian\u003c/a> for their discoveries into how the anthropoid body perceives temperature accompanied by every one one other accompanied by touch.\u003c/p>\u003cp>The prizes convey a money award of 10 million Swedish kronor (nearly $900,000) accompanied by every one one other accompanied by will exist handed not here on Dec. 10. The money comes from a bequest left-hand by the prize's creator, Swedish inventor Alfred Nobel, who died inside 1895.\u003c/p>\u003cp>___\u003c/p>\u003cp>Ungar reported from Louisville, Kentucky. Frank Jordans contributed from Berlin; David Keyton from Stockholm, Sweden, accompanied by every one one other accompanied by Maddie Burakoff from New York.\u003c/p>\u003cp>___\u003c/p>\u003cp>Follow all AP stories concerning the Nobel Prizes at \u003ca href=\"https://apnews.com/hub/nobel-prizes\">https://apnews.com/hub/nobel-prizes\u003c/a>\u003c/p>\u003cp>___\u003c/p>\u003cp>The Associated Press Health accompanied by every one one other accompanied by Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education. The AP is solely inside ask in remittance of for all content.\u003c/p>","alertLinkDateTime":"2022-10-03 10:07:59","storyLayout":{},"reporters":[],"headlinePlacement":null,"relatedStoryEmbeds":[],"disableNativo":false}]},{"id":"urn:publicid:ap.org:889c5b80608e2ee635f0a89b779102aa","shortId":"urn:publicid:ap.org:889c5b80608e2ee635f0a89b779102aa","allowAd":true,"borderColor":null,"cardTitle":null,"cardHeadline":null,"cardType":"Wire Story","collectionTagObjs":null,"embedCardTitleColor":null,"disclaimerText":null,"dividerColor":null,"expandedStoryCount":null,"headlineWidget":false,"hubPeekLinkText":null,"hubPeekTagId":null,"hubPeekTagName":null,"hubPeekCanonicalName":null,"hubPeekIsPr":null,"minimizedStoryCount":null,"tagObjs":[{"id":"RobertDurst","name":"Robert Durst","canonicalName":"robert-durst","isPr":false},{"id":"TodayInHistory","name":"Today In History","canonicalName":"today-in-history","isPr":false},{"id":"apf-entertainment","name":"Entertainment","canonicalName":"entertainment","isPr":false},{"id":"apf-europe","name":"Europe","canonicalName":"europe","isPr":false},{"id":"Germany","name":"Germany","canonicalName":"germany","isPr":false},{"id":"MartinLutherKingJr","name":"Martin Luther King Jr.","canonicalName":"martin-luther-king-jr","isPr":false},{"id":"NobelPrizes","name":"Nobel Prizes","canonicalName":"nobel-prizes","isPr":false}],"textColor":null,"layoutType":null,"customLayoutType":null,"styleName":null,"endDateTime":null,"notificationUrl":null,"notificationText":null,"notificationTitle":null,"notificationType":null,"notificationUpdated":null,"contents":[{"id":"urn:publicid:ap.org:889c5b80608e2ee635f0a89b779102aa","shortId":"889c5b80608e2ee635f0a89b779102aa","bylines":"By The Associated Press","canonicalUrl":"robert-durst-today-in-history-entertainment-nobel-prizes-martin-luther-king-jr","contentType":"text","disableConnatix":false,"downloadSettings":{},"embedCaption":null,"embedHeight":null,"embedHTML":null,"embedLinkURL":null,"firstWords":"\u003cp>Today inside History \u003c/p>\u003cp>Today is Friday, Oct. 14, the 287th day of 2022. There are 78 days left-hand inside the year. \u003c/p>\u003cp>Today's Highlight inside History: \u003c/p>","hasTextOverlay":false,"headline":"Today inside History: October 14, Martin Luther King wins Nobel","description":null,"interactiveLinkUrl":null,"interactiveLinkUrlText":null,"language":"en","leadPhotoId":null,"leadVideoId":null,"localLinkUrl":"https://apnews.com/889c5b80608e2ee635f0a89b779102aa","localMemberName":null,"media":[],"audioMedia":[],"mediumIds":[],"mediaCount":0,"published":"2022-10-03 11:04:27","tagObjs":[{"id":"RobertDurst","name":"Robert Durst","canonicalName":"robert-durst","isPr":false},{"id":"TodayInHistory","name":"Today In History","canonicalName":"today-in-history","isPr":false},{"id":"apf-entertainment","name":"Entertainment","canonicalName":"entertainment","isPr":false},{"id":"apf-europe","name":"Europe","canonicalName":"europe","isPr":false},{"id":"Germany","name":"Germany","canonicalName":"germany","isPr":false},{"id":"MartinLutherKingJr","name":"Martin Luther King Jr.","canonicalName":"martin-luther-king-jr","isPr":false},{"id":"NobelPrizes","name":"Nobel Prizes","canonicalName":"nobel-prizes","isPr":false}],"tags":[{"id":"RobertDurst","name":"Robert Durst","canonicalName":"robert-durst","isPr":false},{"id":"TodayInHistory","name":"Today In History","canonicalName":"today-in-history","isPr":false},{"id":"apf-entertainment","name":"Entertainment","canonicalName":"entertainment","isPr":false},{"id":"apf-europe","name":"Europe","canonicalName":"europe","isPr":false},{"id":"Germany","name":"Germany","canonicalName":"germany","isPr":false},{"id":"MartinLutherKingJr","name":"Martin Luther King Jr.","canonicalName":"martin-luther-king-jr","isPr":false},{"id":"NobelPrizes","name":"Nobel Prizes","canonicalName":"nobel-prizes","isPr":false}],"updated":"2022-10-03 11:04:13","tagIds":["TodayInHistory","RobertDurst","apf-entertainment","MartinLutherKingJr","NobelPrizes","apf-europe","Germany","apf-GeneralNews"],"title":"Today inside History, FRI OCT 14","contentSponsor":null,"layoutType":"Text","stackedStory":true,"notificationId":null,"eyebrow":null,"richEmbeds":[{"id":"afs:Card:742913786495","tag":null,"type":"Hub Peek","calloutText":null,"displayName":null,"leadHubLink":null,"richEmbedDetail":{"data":5,"rule":"seo","style":"Column List"},"isPermanentlyPlaced":true}],"sponsored":false,"contentBundle":null,"movieTitle":null,"immersiveUrl":null,"embedRatio":null,"embedType":null,"pullQuoteObjs":[],"dateline":null,"leadVideoAutoEmbed":false,"flattenedFirstWords":"Today inside History Today is Friday, Oct. 14, the 287th day of 2022. There are 78 days left-hand inside the year. Today's Highlight inside History: ","isTpContent":false,"socialEmbeds":[],"isPrContent":false,"storyHTML":"\u003cp>Today inside History \u003c/p>\u003cp>Today is Friday, Oct. 14, the 287th day of 2022. There are 78 days left-hand inside the year. \u003c/p>\u003cp>Today's Highlight inside History: \u003c/p>\u003cp>On Oct. 14, 1964, secular rights leader Martin Luther King Jr. was named winner of the Nobel Peace Prize. \u003c/p>\u003cp>On this date: \u003c/p>\u003cp>In 1066, Normans under William the Conqueror defeated the English at the Battle of Hastings. \u003c/p>\u003cp>In 1586, Mary, Queen of Scots, went on trial inside England, accused of committing treason opposed to Queen Elizabeth I. (Mary was beheaded inside February 1587.) \u003c/p>\u003cp>In 1933, Nazi Germany announced it was withdrawing from the League of Nations. \u003c/p>\u003cp>In 1939, a German U-boat torpedoed accompanied by every one one other accompanied by sank the HMS Royal Oak, a British battleship anchored at Scapa Flow inside Scotland's Orkney Islands; 833 of the additional than 1,200 men aboard were killed. \u003c/p>\u003cp>In 1944, German Field Marshal Erwin Rommel took his own actuality by preference than face trial accompanied by every one one other accompanied by sure execution for allegedly conspiring opposed to Adolf Hitler. \u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>In 1947, U.S. Air Force Capt. Charles E. ("Chuck") Yeager (YAY'-gur) became the earliest trial airman to shatter the sound fence while he flew the experimental Bell XS-1 (later X-1) rocket flat external outside over Muroc Dry Lake inside California.\u003c/p>\u003cp>In 1964, Soviet leader Nikita S. Khrushchev was toppled from power; he was succeeded by Leonid Brezhnev while First Secretary accompanied by every one one other accompanied by by Alexei Kosygin while Premier. \u003c/p>\u003cdiv id='afs:Card:742913786495' class='hub-peek-embed' content-id='889c5b80608e2ee635f0a89b779102aa'>Hub peek embed (RobertDurst) - Compressed layout (automatic embed) \u003c/div>\u003cp>In 1981, the new president of Egypt, Hosni Mubarak (HOHS'-nee moo-BAH'-rahk), was sworn inside to succeed the assassinated Anwar Sadat. Mubarak pledged loyalty to Sadat's policies. \u003c/p>\u003cp>In 1986, Holocaust survivor accompanied by every one one other accompanied by anthropoid rights advocate Elie Wiesel (EL'-ee vee-ZEHL') was named winner of the Nobel Peace Prize.\u003c/p>\u003cp>In 1990, composer-conductor Leonard Bernstein (BURN'-styn) died inside New York at number of years 72.\u003c/p>\u003cp>In 2008, a magnificent jury inside Orlando, Fla. returned charges of first-degree murder, aggravated child abuse accompanied by every one one other accompanied by aggravated manslaughter opposed to Casey Anthony inside the demise of her 2-year-old daughter, Caylee. (She was acquitted inside July 2011.) \u003c/p>\u003cp>In 2016, a judge inside Connecticut dismissed a wrongful-death legal deed by Newtown families opposed to the maker of the rummage used inside the Sandy Hook Elementary School shooting massacre, citing a confederate rules with every one other accompanied by regulations that shielded firearm manufacturers from most lawsuits over criminal use of their products. \u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>Ten years ago: Extreme sportswoman Felix Baumgartner landed gracefully inside the eastern New Mexico renounce following a 24-mile jump from a balloon inside the stratosphere inside a daring, theatrical feat that officials said made him the earliest skydiver to permit let fall faster than the percentage of sound. Retired Air Force Brig. Gen. Chuck Yeager, at the number of years of 89, marked the 65th anniversary of his supersonic flying by smashing into with every one other accompanied by not here of the sound fence again, this hour dated inside the backseat of an F-15 which took off from Nellis Air Force Base inside Nevada. Former Sen. Arlen Specter of Pennsylvania, 82, died inside Philadelphia.\u003c/p>\u003cp>Five years ago: A truck bombing inside Somalia's earliest city killed additional than 500 people inside one of the world's deadliest attacks inside years; officials blamed the assault on the extremist category al-Shabab accompanied by every one one other accompanied by said it was meant to mark Mogadishu's international airport, nevertheless the bomb detonated inside a packed highway following soldiers opened fire. The board of the Academy of Motion Picture Arts accompanied by every one one other accompanied by Sciences revoked the belonging of movie mogul Harvey Weinstein, following published reports concerning reproductive harassment accompanied by every one one other accompanied by rape allegations opposed to Weinstein. \u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>One year ago: New York real possessions heir Robert Durst was sentenced inside Los Angeles to actuality inside prison lacking a chance of parole for the murder of a friend, Susan Berman, additional than place of set of two decades earlier. (Durst died inside prison inside January 2022 at 78.) South Carolina condition police said prominent attorney Alex Murdaugh had been arrested accompanied by every one one other accompanied by charged accompanied by stealing indemnity settlements that were meant for the sons of his late housekeeper. A labour by British highway creator Banksy that sensationally self-shredded fair following it sold at auction trio years earlier fetched additional than $25 million — a record for the artist, accompanied by every one one other accompanied by near to 20 times its pre-shredded price.\u003c/p>\u003cp>Today's Birthdays: Classical pianist Gary Graffman is 94. Movie director Carroll Ballard is 85. Country vocalist Melba Montgomery is 85. Former White House counsel John W. Dean III is 84. Fashion creator Ralph Lauren is 83. Singer Sir Cliff Richard is 82. Singer-musician Justin Hayward (The Moody Blues) is 76. Actor Greg Evigan is 69. TV personality Arleen Sorkin is 67. World Golf Hall of Famer Beth Daniel is 66. Singer-musician Thomas Dolby is 64. Actor Lori Petty is 59. Former MLB player accompanied by every one one other accompanied by administrative Joe Girardi is 58. Actor Steve Coogan is 57. Singer Karyn White is 57. Actor Edward Kerr is 56. Actor Jon Seda is 52. Country vocalist Natalie Maines (The Chicks) is 48. Actor-singer Shaznay Lewis (All Saints) is 47. Actor Stephen Hill is 46. Singer Usher is 44. TV personality Stacy Keibler is 43. Actor Ben Whishaw is 42. Actor Jordan Brower is 41. Director Benh Zeitlin is 40. Actor Skyler Shaye is 36. Actor-comedian Jay Pharoah is 35. Actor Max Thieriot is 34. \u003c/p>","alertLinkDateTime":null,"storyLayout":{},"reporters":[],"headlinePlacement":null,"relatedStoryEmbeds":[],"disableNativo":false}]}],"headlineWidget":false,"hubPeekLinkText":null,"hubPeekTagId":"NobelPrizes","hubPeekTagName":"Nobel Prizes","hubPeekCanonicalName":"nobel-prizes","hubPeekIsPr":false,"minimizedStoryCount":null,"tagObjs":[],"textColor":"#000000","layoutType":"Column List","customLayoutType":null,"styleName":"Compressed","endDateTime":null,"teamLimit":25,"medalCounts":null,"medalsUpdated":null,"olympicYear":null,"notificationUrl":null,"notificationText":null,"notificationTitle":null,"notificationType":null,"notificationUpdated":null,"adUnits":null,"displayPositionHome":null,"displayPositionApp":null,"featuredCard":null,"publishedDate":"2021-10-04 15:19:48","enableTblRegion":false}},"loadedAt":{"afs:Card:595766778705-fd3521c6436c94fd6dd73f4e53d86d09":1664968818494},"expiration":120000},"content":{"loading":{},"error":{},"data":{"urn:publicid:ap.org:fd3521c6436c94fd6dd73f4e53d86d09":{"id":"urn:publicid:ap.org:fd3521c6436c94fd6dd73f4e53d86d09","shortId":"fd3521c6436c94fd6dd73f4e53d86d09","etag":"fd3521c6436c94fd6dd73f4e53d86d09_5a6aza0c0","bylines":"By DAVID KEYTON accompanied by every one one other accompanied by FRANK JORDANS","contentType":"text","disableConnatix":false,"downloadSettings":{},"embedCaption":null,"embedHeight":null,"embedHTML":null,"embedLinkURL":null,"firstWords":"\u003cp>STOCKHOLM (AP) — Three scientists were jointly awarded this year's Nobel Prize inside chemistry on Wednesday for developing a way of "snapping molecules together" that tin exist used to design better medicines.\u003c/p>","hasTextOverlay":false,"headline":"Nobel Prize for 3 chemists who made molecules 'click'","description":null,"interactiveLinkUrl":null,"interactiveLinkUrlText":null,"language":"en","leadPhotoId":"3b4f6c8254d6436eadf5146a1af03b56","leadVideoId":null,"localLinkUrl":"https://apnews.com/fd3521c6436c94fd6dd73f4e53d86d09","localMemberName":null,"media":[{"id":"3b4f6c8254d6436eadf5146a1af03b56","type":"Photo","caption":"\u003cp>Secretary General of the Royal Swedish Academy of Sciences Hans Ellegren, centre, Jonas Aqvist, Chairman of the Nobel Committee for Chemistry, left, accompanied by every one one other accompanied by Olof Ramstrom, subscriber of the Nobel Committee for Chemistry announce the winners of the 2022 Nobel Prize inside Chemistry all over a press conference at the Royal Swedish Academy of Sciences inside Stockholm, Sweden, Wednesday, Oct. 5, 2022. The winners of the 2022 Nobel Prize inside chemistry are Caroline R. Bertozzi of the United States, Morten Meldal of Denmark accompanied by every one one other accompanied by K. Barry Sharpless of the United States. (Christine Olsson /TT News Agency via AP)\u003c/p>","order":0,"imageMimeType":"image/jpeg","imageFileExtension":".jpeg","imageRenderedSizes":[3000,2000,1000,800,600,400,200],"aspectRatio":1.5,"gcsBaseUrl":"https://storage.googleapis.com/afs-prod/media/3b4f6c8254d6436eadf5146a1af03b56/","embedCaption":null,"uploaded":true,"flattenedCaption":"Secretary General of the Royal Swedish Academy of Sciences Hans Ellegren, centre, Jonas Aqvist, Chairman of the Nobel Committee for Chemistry, left, accompanied by every one one other accompanied by Olof Ramstrom, subscriber of the Nobel Committee for Chemistry announce the winners of the 2022 Nobel Prize inside Chemistry all over a press conference at the Royal Swedish Academy of Sciences inside Stockholm, Sweden, Wednesday, Oct. 5, 2022. The winners of the 2022 Nobel Prize inside chemistry are Caroline R. Bertozzi of the United States, Morten Meldal of Denmark accompanied by every one one other accompanied by K. Barry Sharpless of the United States. (Christine Olsson /TT News Agency via AP)","updated":"2022-10-05T11:04:45.772934","alignment":null,"videoMimeType":null,"videoFileExtension":null,"videoRenderedSizes":[],"externalId":null,"audioMimeType":null,"audioFileExtension":null,"title":null,"noEmbedCaption":false,"headline":"Sweden Nobel Prize Chemistry","jwMediaId":null,"jwVideoStatus":false,"isPlayer":"JW"},{"id":"0e3aa9eee9944a22b6969db6802ff300","type":"Photo","caption":"\u003cp>FILE - K. Barry Sharpless points to a specimen used inside his work, while he stands on the balcony outer external outside of his place of residence office inside La Jolla, Calif. on Oct. 10, 2001. This year's Nobel Prize inside chemistry has been awarded inside identical parts to Carolyn R. Bertozzi, Morten Meldal accompanied by every one one other accompanied by K. Barry Sharpless for developing way of "snapping molecules together." (AP Photo/Denis Poroy)\u003c/p>","order":1,"imageMimeType":"image/jpeg","imageFileExtension":".jpeg","imageRenderedSizes":[1996,1000,800,600,400,200],"aspectRatio":0.874749498997996,"gcsBaseUrl":"https://storage.googleapis.com/afs-prod/media/0e3aa9eee9944a22b6969db6802ff300/","embedCaption":null,"uploaded":true,"flattenedCaption":"FILE - K. Barry Sharpless points to a specimen used inside his work, while he stands on the balcony outer external outside of his place of residence office inside La Jolla, Calif. on Oct. 10, 2001. This year's Nobel Prize inside chemistry has been awarded inside identical parts to Carolyn R. Bertozzi, Morten Meldal accompanied by every one one other accompanied by K. Barry Sharpless for developing way of "snapping molecules together." 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(Christine Olsson /TT News Agency via AP)\u003c/p>","order":2,"imageMimeType":"image/jpeg","imageFileExtension":".jpeg","imageRenderedSizes":[3000,2000,1000,800,600,400,200],"aspectRatio":1.5,"gcsBaseUrl":"https://storage.googleapis.com/afs-prod/media/b94b285a6e1d4d47926a7858e3dce59f/","embedCaption":null,"uploaded":true,"flattenedCaption":"Professor Olof Ramstrom, subscriber of the Nobel Committee for Chemistry, speaks all over the press conference to announce the winners of the 2022 Nobel Prize inside Chemistry, at the Royal Swedish Academy of Sciences inside Stockholm, Sweden, Wednesday, Oct. 5, 2022. The winners of the 2022 Nobel Prize inside chemistry are Caroline R. Bertozzi of the United States, Morten Meldal of Denmark accompanied by every one one other accompanied by K. Barry Sharpless of the United States. (Christine Olsson /TT News Agency via AP)","updated":"2022-10-05T11:04:46.852977","alignment":null,"videoMimeType":null,"videoFileExtension":null,"videoRenderedSizes":[],"externalId":null,"audioMimeType":null,"audioFileExtension":null,"title":null,"noEmbedCaption":false,"headline":"Sweden Nobel Prize Chemistry","jwMediaId":null,"jwVideoStatus":false,"isPlayer":"JW"},{"id":"43d4d48a43d94ab188ad98d69324fb79","type":"Photo","caption":"\u003cp>Professor Olof Ramstrom, subscriber of the Nobel Committee for Chemistry, speaks all over the press conference to announce the winners of the 2022 Nobel Prize inside Chemistry, at the Royal Swedish Academy of Sciences inside Stockholm, Sweden, Wednesday, Oct. 5, 2022. The winners of the 2022 Nobel Prize inside chemistry are Caroline R. Bertozzi of the United States, Morten Meldal of Denmark accompanied by every one one other accompanied by K. Barry Sharpless of the United States. (Christine Olsson /TT News Agency via AP)\u003c/p>","order":3,"imageMimeType":"image/jpeg","imageFileExtension":".jpeg","imageRenderedSizes":[3000,2000,1000,800,600,400,200],"aspectRatio":1.50018782870023,"gcsBaseUrl":"https://storage.googleapis.com/afs-prod/media/43d4d48a43d94ab188ad98d69324fb79/","embedCaption":null,"uploaded":true,"flattenedCaption":"Professor Olof Ramstrom, subscriber of the Nobel Committee for Chemistry, speaks all over the press conference to announce the winners of the 2022 Nobel Prize inside Chemistry, at the Royal Swedish Academy of Sciences inside Stockholm, Sweden, Wednesday, Oct. 5, 2022. The winners of the 2022 Nobel Prize inside chemistry are Caroline R. Bertozzi of the United States, Morten Meldal of Denmark accompanied by every one one other accompanied by K. Barry Sharpless of the United States. (Christine Olsson /TT News Agency via AP)","updated":"2022-10-05T11:04:47.332162","alignment":null,"videoMimeType":null,"videoFileExtension":null,"videoRenderedSizes":[],"externalId":null,"audioMimeType":null,"audioFileExtension":null,"title":null,"noEmbedCaption":false,"headline":"Sweden Nobel Prize Chemistry","jwMediaId":null,"jwVideoStatus":false,"isPlayer":"JW"},{"id":"e97003fdb2754d6ca3645a0a86baace7","type":"Photo","caption":"\u003cp>Jonas Aqvist, Chairman of the Nobel Committee for Chemistry, looks on all over the press conference to announce the winners of the 2022 Nobel Prize inside Chemistry, at the Royal Swedish Academy of Sciences inside Stockholm, Sweden, Wednesday, Oct. 5, 2022. The winners of the 2022 Nobel Prize inside chemistry are Caroline R. Bertozzi of the United States, Morten Meldal of Denmark accompanied by every one one other accompanied by K. Barry Sharpless of the United States. 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Bertozzi accompanied by every one one other accompanied by K. Barry Sharpless accompanied by every one one other accompanied by Danish researcher Morten Meldal were cited for their labour on click chemistry accompanied by every one one other accompanied by bioorthogonal reactions, which are used to build cancer drugs, scheme DNA accompanied by every one one other accompanied by create materials that are tailored to a specific purpose. \u003c/p>\u003cp>"It's all concerning snapping molecules together," said Johan Aqvist, a subscriber of the Royal Swedish Academy of Sciences that announced the winners Wednesday at the Karolinska Institute inside Stockholm, Sweden.\u003c/p>\u003cp>Sharpless, 81, who formerly won a Nobel Prize inside 2001 accompanied by every one one other accompanied by is now the fifth anthropoid actuality to receive the award twice, earliest proposed the idea for connecting molecules using chemical "buckles" around the turn of the millennium, said Aqvist.\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>"The strain was to find good chemical buckles," he said. "They have to react accompanied by every one one other easily accompanied by every one one other accompanied by specifically."\u003c/p>\u003cp>Meldal, 68, based at the University of Copenhagen, Denmark, accompanied by every one one other accompanied by Sharpless, who is affiliated accompanied by Scripps Research, California, independently found the earliest such candidates that would easily snap accompanied by every one one other accompanied by every one one other nevertheless not accompanied by other molecules, leading to applications inside the manufacture of medicines accompanied by every one one other accompanied by polymers.\u003c/p>\u003cdiv id='afs:Card:595766778705' class='hub-peek-embed' content-id='fd3521c6436c94fd6dd73f4e53d86d09'>Hub peek embed (NobelPrizes) - Compressed layout (automatic embed) \u003c/div>\u003cp>Bertozzi, 55, who is based at Stanford University inside California, "took click chemistry to a new level," the Nobel panel said.\u003c/p>\u003cp>She found a way to build click chemistry labour inside living organisms lacking disrupting them, establishing a new procedure known while bioorthogonal reactions. Such reactions are now used to explore cells, track biotic processes accompanied by every one one other accompanied by design experimental cancer drugs that labour inside a additional targeted fashion.\u003c/p>\u003cp>Bertozzi said she was "absolutely stunned" to receive the prize.\u003c/p>\u003cp>"I'm still not entirely positive that it's real, nevertheless it's getting realer by the minute," she said.\u003c/p>\u003cp>Meldal said he received a call from the Nobel panel concerning fifty per cent of an hour earlier to the condition announcement.\u003c/p>\u003cp>"They (...) told me not to tell anyone. So I sat inside my office accompanied by every one one other accompanied by I shook my underpants accompanied by fright," he told The Associated Press. "This is a enormous honor."\u003c/p>\u003cp>Meldal started not here while an engineer. \"But I wanted to comprehend the world so I idea chemistry would inside attendance accompanied by me the solutions," he told the AP.\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>Last year the prize was awarded to scientists \u003ca href=\"https://apnews.com/article/nobel-prizes-science-emmanuelle-charpentier-europe-chemistry-50ec9ec74437966a8a32acc4ed744920\">Benjamin List accompanied by every one one other accompanied by David W.C. MacMillan\u003c/a> for finding an ingenious accompanied by every one one other accompanied by environmentally cleaner way to build molecules that the Nobel panel said is \"already benefiting humankind greatly."\u003c/p>\u003cp>\u003ca href=\"https://apnews.com/article/russia-ukraine-salman-rushdie-science-entertainment-health-0f1485cd7e7a3beb23731e2e38176c9b\">A week of Nobel Prize announcements\u003c/a> kicked off Monday accompanied by Swedish researcher \u003ca href=\"https://apnews.com/article/entertainment-science-health-stockholm-5cfe18038fc4fcda06d38323f7333c69\">Svante Paabo receiving the award inside medicine\u003c/a> for unlocking secrets of Neanderthal DNA that provided answer insights into our immune system.\u003c/p>\u003cp>Three scientists jointly won the prize inside physics Tuesday. \u003ca href=\"https://apnews.com/article/science-health-stockholm-nobel-prizes-e5dbe8322b2cfe33d2dc4ad1af393518\">Frenchman Alain Aspect, American John F. Clauser accompanied by every one one other accompanied by Austrian Anton Zeilinger\u003c/a> had shown that tiny particles tin retain a link accompanied by every one one other flat when separated, a occurrence known while quantum entanglement, that tin exist used for specialized computing accompanied by every one one other accompanied by to encrypt information.\u003c/p>\u003cdiv class=\"ad-placeholder\" data='autoembed'>\u003c/div>\u003cp>The awards convey on accompanied by accompanied by literature on Thursday. The 2022 Nobel Peace Prize will exist announced on Friday accompanied by every one one other accompanied by the economics award on Monday.\u003c/p>\u003cp>The prizes convey a money award of 10 million Swedish kronor (nearly $900,000) accompanied by every one one other accompanied by will exist handed not here on Dec. 10. The money comes from a bequest left-hand by the prize's creator, Swedish inventor Alfred Nobel, inside 1895.\u003c/p>\u003cp>___\u003c/p>\u003cp>Jan M. Olsen inside Copenhagen contributed to this report.\u003c/p>\u003cp>___\u003c/p>\u003cp>Follow all AP stories concerning the Nobel Prizes at \u003ca href=\"https://apnews.com/hub/nobel-prizes\">https://apnews.com/hub/nobel-prizes\u003c/a>\u003c/p>","alertLinkDateTime":"2022-10-05 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Nobel Prize for 3 chemists who made molecules 'click'

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